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Asymmetric ring opening of cyclic acid anhydrides with lipase in organic solvents

✍ Scribed by Kazuyoshi Yamamoto; Takaaki Nishioka; Jun'ichi Oda; Yukio Yamamoto

Book ID: 104217469
Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 268 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)82026-2

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✦ Synopsis

A lipase (Amano P) catalyzed the asymmetric ring opening of 3-substituted glutaric anhydride with l-butanol to afford the E half esters having 60-91%ee.

Asymmetric synthesis and kinetically resolution with enzymes has been well appreciated as an efficient strategy to prepare optically active comp0unds.l

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