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Asymmetric Reductive Ring-Opening of Bicyclic Olefins Catalyzed by Palladium and Nickel Complexes

โœ Scribed by Li, Lih-Ping; Rayabarapu, Dinesh Kumar; Nandi, Malay; Cheng, Chien-Hong


Book ID
126445598
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
80 KB
Volume
5
Category
Article
ISSN
1523-7060

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Scope of the nickel catalyzed asymmetric
โœ Mark Lautens; Tomislav Rovis ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 531 KB

Subjecting a variety of oxabicyclo[2.2.1lheptenes to diisobutylaluminum hydride (DIBAL-H) in the presence of a catalytic amount of Ni(COD) 2 and (R)-BINAP results in a highly enantioselective ring opening to generate cyciohexenois with ee's typically greater than 90%. The scope of this reaction has