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Asymmetric reduction of ketone reductive cleavage of chiral acetals using organoaluminum reagents

✍ Scribed by Atsunori Mori; Junya Fujiwara; Keiji Maruoka; Hisashi Yamamoto

Book ID: 104219938
Publisher: Elsevier Science
Year: 1983
Tongue: French
Weight: 229 KB
Volume: 24
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)85961-4

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✦ Synopsis

Some chiral acetals are cleaved by organoaluminum reagents. The products are formed diastereoselectively, and the removal of the chiral auxiliary affords optically active alcohols. A recent communication by Bartlett, Johnson and Elliott1 on the acetal derived from (-)-(2$4_R)-2,4-pentanediol has prompted us to report our own efforts in this area.

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