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Asymmetric reduction of .alpha.-keto esters with potassium 9-O-(1,2:5,6-di-O-isopropylidene-.alpha.-D-glucofuranose)-9-boratabicyclo[3.3.1]nonane. Chiral synthesis of .alpha.-hydroxy esters with optical purity approaching 100% ee

โœ Scribed by Brown, Herbert C.; Cho, Byung Tae; Park, Won Suh


Book ID
127201369
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
436 KB
Volume
51
Category
Article
ISSN
0022-3263

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Asymmetric reduction of ฮฑ-keto acetals w
โœ Byung Tae Cho; Yu Sung Chun ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 226 KB

Asymmetric reduction of a-keto acetals with a chiral borohydride, potassiun 9-0-(1~-isopropylidcnt-5-doxy-a-Dxylofuranosyl)-~~~clo[3.3.l]nonane in 'IHF at -78ยฐC provided the corresponding a-hydn-rxy acetals with 87 -99 % ee. Optically active a-hydroxy aldehydes are useful chit-al building blocks for