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Asymmetric palladium-catalyzed annulation of benzene-1,2-diol and racemic secondary propargylic carbonates bearing two different substituents

✍ Scribed by Norbert Dominczak; Céline Damez; Bouchra Rhers; Jean-Robert Labrosse; Paul Lhoste; Boguslaw Kryczka; Denis Sinou


Book ID
108282884
Publisher
Elsevier Science
Year
2005
Tongue
French
Weight
313 KB
Volume
61
Category
Article
ISSN
0040-4020

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The reaction of benzene-1,2-diol with various propargylic carbonates in the presence of a palladium catalyst and various chiral ligands afforded the corresponding 2-alkylidene-3-alkyl-2,3-dihydrobenzodioxins in quite good yields and enantioselectivities of up to 97%. The highest enantiomeric ex- [a]

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The palladium-catalyzed cyclization of benzene-1,2-diol with various secondary propargylic carbonates in the presence of (R)-Binap as the chiral ligand afforded the corresponding 2,3-dihydrobenzo-1,4-dioxin derivatives in quite good yields, and also in enantioselectivities of up to 93%. The assumed