Asymmetric palladium-catalyzed annulation of benzene-1,2-diol and racemic secondary propargylic carbonates bearing two different substituents
✍ Scribed by Norbert Dominczak; Céline Damez; Bouchra Rhers; Jean-Robert Labrosse; Paul Lhoste; Boguslaw Kryczka; Denis Sinou
- Book ID
- 108282884
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- French
- Weight
- 313 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0040-4020
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The reaction of benzene-1,2-diol with various propargylic carbonates in the presence of a palladium catalyst and various chiral ligands afforded the corresponding 2-alkylidene-3-alkyl-2,3-dihydrobenzodioxins in quite good yields and enantioselectivities of up to 97%. The highest enantiomeric ex- [a]
The palladium-catalyzed cyclization of benzene-1,2-diol with various secondary propargylic carbonates in the presence of (R)-Binap as the chiral ligand afforded the corresponding 2,3-dihydrobenzo-1,4-dioxin derivatives in quite good yields, and also in enantioselectivities of up to 93%. The assumed