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Asymmetric Michael additions via SAMP-/RAMP-hydrazones anti-diastereo- and enantioselective synthesis of 3,4-disubstituted 5-oxo-alkanoates

✍ Scribed by Dieter Enders; Kyriakos Papadopoulos; Beatrice E.M Rendenbach; Rolf Appel; Falk Knoch

Book ID
104218910
Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
247 KB
Volume
27
Category
Article
ISSN
0040-4039

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Asymmetric Michael Additions via 6-and 7-Membered Lactone SAMP-Hydrazones: Diastereo-and Enantioselective Synthesis of Substituted Lactone Esters. -High asymmetric inductions are achieved in the Michael addition of hydrazones (I) to Ξ±,Ξ²-unsaturated esters (II). Removal of the chiral auxiliary by ozo