✦ LIBER ✦

Asymmetric metabolic N-oxidation of N-ethyl-N-methylaniline by purified flavin-containing monooxygenase

✍ Scribed by Mark R. Hadley; Harriet G. Oldham; Lyaquatali A. Damani; Dr. Andrew J. Hutt

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 720 KB
Volume: 6
Category: Article
ISSN: 0899-0042
DOI: 10.1002/chir.530060210

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

An Assay of Flavin-Containing Monooxygen

An Assay of Flavin-Containing Monooxygenase Activity with Benzydamine N-Oxidation

✍ A. Kawaji; K. Ohara; E. Takabatake 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 323 KB

An assay system of flavin-containing monooxygenase was developed by fluorometric determination of benzydamine (BZY) N-oxidation with HPLC. The apparent Km value for the formation of BZY N-oxide from BZY by rat liver microsomes was similar to that by purified FMO. The Km and Vmax values for the forma

Metabolism of 4-substituted-N-ethyl-N-me

Metabolism of 4-substituted-N-ethyl-N-methylanilines: Chromatographic and mass spectrometric identification of N-oxidation metabolic products formed in vitro

✍ David A. Cowan; Laurence H. Patterson; Lyaquatali A. Damani; John W. Gorrod 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 630 KB

Flavin-containing monooxygenase isoform

Flavin-containing monooxygenase isoform specificity for the N-oxidation of tamoxifen determined by product measurement and NADPH oxidation

✍ Ernest Hodgson; Randy L. Rose; Yan Cao; Shangara S. Dehal; David Kupfer 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 62 KB

The K m value for tamoxifen is 1.2 mM for mouse FMO1 (human FMO1 is not expressed in adults) and 1.4 mM for human FMO3, with no detectable activity being expressed toward tamoxifen by FMO5 from either mouse or human. These data are derived from experiments using 3 H-tamoxifen as substrate in which t

A model for metabolic activation of dial

A model for metabolic activation of dialkylnitrosamines. Oxidative dealkylation of N-nitroso-2-(alkylamino)acetonitrile by flavin mimic in aqueous solution

✍ Yumihiko Yano; Takeshi Yokoyama; Kitaro Yoshida 📂 Article 📅 1986 🏛 Elsevier Science 🌐 French ⚖ 232 KB

Oxidation-active flavin mimic, benzo[l,2-g, 5,4\_g']dipteridine (BDP), is found to react with N-nitroso-2-(alkylamino)acetonitrile via oxidative dealkylation in aqueous solution. From the kinetic investigations, the oxidation mechanism is proposed.