In the presence of 2,6-diisopropylphenol and t-BuOMe (1 equiv. each), asymmetric Mukaiyama-Michael reaction of a variety of benzalacetone derivatives 2 with silyl ketene acetal 3 is efficiently catalyzed by O-(2-naphthoyl)-N-tosyl-(L)-allo-threonine-derived B-phenyloxazaborolidinone 1 (10 mol%) to g
Asymmetric Intramolecular Michael Reaction Catalyzed by Proline-Derived Small Anilides.
β Scribed by Makoto Kikuchi; Tomohiko Inagaki; Hisao Nishiyama
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 21 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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Supporting information for this article is available on the WWW under http://dx.doi.org/10.1002/chem.200902303. Scheme 1. Organocatalyzed tandem intramolecular oxa-Michael addition/ electrophilic fluorination reaction to access chiral fluorinated flavanones.