Asymmetric induction in kinetically controlled zirconium-catalysed Meerwein-Ponndorf-Verley reductions
✍ Scribed by Karsten Krohn; Birgit Knauer
- Book ID
- 104589824
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 468 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0165-0513
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## Abstract The new variation of the Meerwein‐Ponndorf‐Verley reduction using 1‐[4‐(dimethylamino)phenyl]ethanol (DMAPE) (6) or 1‐tetralol (12) (3 equiv.) as the reducing alcohols and Zr(O‐__t__Bu)~4~ as the catalyst (0.2 equiv.) is kinetically controlled and highly stereoselective. Preferential ax
## Abstract The reduction of acetophenone using a chiral catalyst, prepared __in situ__ by adding a chiral dihydroxy compound to a solution of a lanthanide(III) alkoxide, was studied. The highest enantiomeric excess (ee) (32%) was observed with La(O′Bu)~3~ as the catalyst and 1,2:5,6‐di‐__O__‐isopr