Asymmetric Friedel-Crafts reaction mediated by new chiral auxiliaries derived from (1S)-(−)-β-pinene: Enantioselective synthesis of (−)-8-Norethyl, 1′-normethyl Etodolac

✍ Scribed by Paulo R.R. Costa; Lúcio M. Cabral; Karla G. Alencar; Luciana L. Schmidt; Mário L.A.A. Vasconcellos

• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 192 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)01658-4

✦ Synopsis

8-Norethyl, l'-normethyl Etodolac (-)-7 was synthesized in ¢¢ up to 95% from a Frie,,dcI-Cratts alkylation reaction between tryptophol 4 and the chiral I~-ketobutyrat¢ 5h, followed by hydrolysis.