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Asymmetric Double-Bond Isomerization of 4,7-Dihydro- to 4,5-Dihydro-1,3-dioxepins

✍ Scribed by Dr. Herbert Frauenrath; Thomas Philipps


Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
116 KB
Volume
25
Category
Article
ISSN
0044-8249

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The reaction of 3-mercapto-4-aryIideneamino-l,2,4triazoles 2b-d, 3a-d with ethyl bromoacetate and/or phenacyl bromide in hot DMF and triethylamine affords the stereochemically pure 7-acyl-6-aryl-6,7dihydro-5H-lt2, 4-triazolo[3,4-b][l, 3,4]thiadiazines