Asymmetric Conjugate Reductions of Coumarins. A New Route to Tolterodine and Related Coumarin Derivatives
β Scribed by Gallagher, Brian D.; Taft, Benjamin R.; Lipshutz, Bruce H.
- Book ID
- 118140943
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 344 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1523-7060
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## Abstract A new and efficient conjugate addition of trimethyl and triethyl phosphites to 3βΟβazidoacetylcoumarin **(****1****)** has been studied. The reaction proceeded smoothly at r.t. furnishing 1,2,3,4βtriazaphosphole coumarin derivatives **4a**, **4b** in βΌ75% yields. Linear substituted tria