Asymmetric Conjugate Addition of Glycine Derivatives under Copper Catalysis

✍ Scribed by Dr. Mark Strohmeier; Kevin Leach; Dr. Matthew A. Zajac

• Book ID: 102731422
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 506 KB
• Volume: 50
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.201105258

✦ Synopsis

Pyrrolidines are ubiquitous substructures which are incorporated into varied pharmaceutical and natural product targets, and significant efforts have surrounded their syntheses. [1] Although many synthetic approaches have been developed for their formation, [1, 2] we became interested in an inexpensive, scalable, asymmetric, and sustainable synthesis that would allow access to medicinally relevant derivatives of 1 (Scheme 1). Cycloaddition is a well-established method of