Asymmetric Catalytic Hydroamination of Activated Olefins in Ionic Liquids

✍ Scribed by Luca Fadini; Antonio Togni

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: German
• Weight: 229 KB
• Volume: 90
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200790048

✦ Synopsis

Abstract

The addition of a series of both aliphatic and aromatic amines to electron‐poor olefins was investigated using [Ni(Pigiphos)(THF)]^2+^ as catalyst (with different counterions) in various ionic liquids based on imidazolium‐ and picolinium‐salt derivatives. The catalysts gave rise to selectivities comparable to those obtained when the reaction was conducted in neat organic solvents (ee up to 66%), but significant higher activities, with a total turnover number (TON) of up to 300.