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Asymmetric bromolactonization reaction: Synthesis of optically active 2-hydroxy-2-methylalkanoic acids from 2-methylenealkanoic acids

✍ Scribed by Paul F Corey

Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 207 KB
Volume: 28
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)96213-0

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✦ Synopsis

Optically pure 2-hydroxy-2-methylalkanoic acids of either configuration may be obtained via an asymmetric bromolactonization reaction using &-proline as a chiral auxilliary.

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