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Asymmetric Autocatalysis and Its Application to Chiral Discrimination

✍ Scribed by Kenso Soai; Itaru Sato


Publisher
John Wiley and Sons
Year
2003
Weight
48 KB
Volume
34
Category
Article
ISSN
0931-7597

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Chiral pyrimidyl, quinolyl, and pyridyl alkanols act as asymmetric autocatalysts with significant amplification of enantiomeric excess (ee) in the enantioselective addition of diisopropylzinc to pyrimidine-5-, quinoline-3-, and pyridine-3-carbaldehydes, respectively. 2-Alkynyl-5-pyrimidyl alkanol wi

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Chirality, that is, the handedness of compounds, has attracted the broad interest of many scientists. One of the most characteristic features of chirality is that all living organisms on earth are composed of highly enantioenriched L-amino acids and D-sugars. Prebiotic processes which lead to these