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Asymmetric aldol reaction of amide enolates bearing trans-2,5-disubstituted pyrrolidines as chiral auxiliaries

✍ Scribed by Tsutomu Katsuki; Masaru Yamaguchi

Publisher: Elsevier Science
Year: 1985
Tongue: French
Weight: 244 KB
Volume: 26
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)98932-9

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✦ Synopsis

Condensation of aldehydes with Zr enolate of chiral N-propionyl-trans-2,5_disubstituted

pyrrolidine proceeded with high diastereo-and diastereofaceselection. Stereoselectivity in the reaction of the corresponding N-acetyl compounds was also examined.

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