## Abstract For Abstract see ChemInform Abstract in Full Text.
Asymmetric Addition to Ketones: Enantioselective Formation of Tertiary Alcohols
β Scribed by Celina Garcia; Victor S. Martin
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 11 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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## Abstract (__S__)β(1βBenzylpyrrolidinβ2βyl)diphenylmethanol and cinchonine were evaluated as promotors in the asymmetric additions of phenylacetylene to ketones, in order to prepare chiral propargylic alcohols. Good yields (up to 89%) and moderate enantioselectivities (up to 77.9% __ee__) were ac
Ru(CNtBu) , (CH,Ph),] (9) and [Ru(CNfBu),(SiMe,Cl),] (10) were both isolated in good yield (78 % and 71 %, respectively). NMR spectra indicate that 10, like 4 and 7, is formed as the trans isomer, while 9, surprisingly, is formed as the cis. Extensions of these reactions to more complex alkyls hav