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Asymmetric Addition of Terminal Acetylenes to Aldehydes, Catalyzed by Zn(OTf)2—Cinchona Alkaloid Complexes.

✍ Scribed by Jesper Ekstroem; Alexey B. Zaitsev; Hans Adolfsson


Publisher
John Wiley and Sons
Year
2006
Weight
22 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract A new catalytic system, generated from the readily available and inexpensive β‐sulfonamide alcohol L\*, Ti(O^i^Pr)~4~, Et~2~Zn, and tertiary amine base (R~3~N), effectively catalyzes the enantioselective addition of various terminal alkynes including some quite challenging alkynes to al