Asymmetic Microsomal Epoxidation of Simple Prochiral Olefins

✍ Scribed by Prof. Dr. Volker Schurig; Dipl.-Chem. Dorothee Wistuba

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 254 KB
• Volume: 23
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.198407961

✦ Synopsis

1 (10.9 mmol) in a stream of dry Nz is passed into a stirred solution of LiOCMe, (30.5 mmol) in 40 mL n-pentane at -60°C. The coolant is removed and the mixture gently warmed up to room temperature and stirred for 12 h. The solvent is then carefully removed, resulting in formation of a yellow, glass-like solid, which is taken up in n-pentane and cooled to -35°C. The solvent is slowly removed at this temperature. Crystals of 5 , which can be separated manually, are included in the residual solid. 5 decomposes immediately at room temperature in vacuo, but under N2 is stable for a few hours. If they are imbedded into KelF wax, the crystals can be stored for several weeks.