Asymetric conjugate addition of copper azaenolates as synthetic equivalent of enolates to cyclic enones

✍ Scribed by Keiji Yamamoto; Masayuki Iijima; Yoshinobu Ogimura

• Book ID: 104221932
• Publisher: Elsevier Science
• Year: 1982
• Tongue: French
• Weight: 259 KB
• Volume: 23
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)88664-5

✦ Synopsis

Asymmetric conlugate addltlon to prochlral cyclic enones was devised by using copper azaenolates derived from an acetone lmlne of optically active amino ethers which were prepared from cr-amino acids, the optical yields of the resulting 3-acetonylcycloalkanones being found to attain as high as 75% e. e.