✦ LIBER ✦

Astrocytoma as a second malignancy in patients with acute lymphoblastic leukemia

✍ Scribed by Marian Malone; Hilary Lumley; Magda Erdohazi

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 969 KB
Volume: 57
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19860515)57:10<1979::aid-cncr2820571016>3.0.co;2-r

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✦ Synopsis

Three cases of astrocytoma, two cerebral (grades I1 and 111) and one spinal (grade 11) occurring as second malignancies in patients with previously diagnosed acute lymphoblastic leukemia are described. All had received prophylactic cranial irradiation and intrathecal methotrexate. All were in remission at the time of development of the second malignancy. The time interval between central nervous system (CNS) prophylaxis and symptoms of CNS tumor was between 3 and 5 years. The possible causes of the combination of astrocytoma with acute lymphoblastic leukemia are discussed.

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