Astrocytes overexpressing Cu,Zn superoxide dismutase have increased resistance to oxidative injury

Peroxiredoxin 2 overexpression protects

Peroxiredoxin 2 overexpression protects cortical neuronal cultures from ischemic and oxidative injury but not glutamate excitotoxicity, whereas Cu/Zn superoxide dismutase 1 overexpression protects only against oxidative injury

✍ Sherif Boulos; Bruno P. Meloni; Peter G. Arthur; Christina Bojarski; Neville W. 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 410 KB

## Abstract We previously reported that peroxiredoxin 2 (PRDX2) and Cu/Zn superoxide dismutase 1 (SOD1) proteins are up‐regulated in rat primary neuronal cultures following erythropoietin (EPO) preconditioning. In the present study, we have demonstrated that adenovirally mediated overexpression of