๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Astrocytes in cerebral ischemic injury: Morphological and general considerations

โœ Scribed by Kiran S. Panickar; Michael D. Norenberg

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
453 KB
Volume
50
Category
Article
ISSN
0894-1491

No coin nor oath required. For personal study only.

โœฆ Synopsis

Abstract

Asrocytic responses constitute one of the earliest and most prominent changes in the CNS following ischemic injury. Astrocytes are known to carry out critical functions such as maintenance of ionic homeostasis, prevention of excitotoxicity, scavenging free radicals, provision of nutrients and growth factors, promotion of neovascularization, and support of synaptogenesis and neurogenesis that potentially may influence the outcome of ischemic injury. This article reviews ischemiaโ€associated alterations in astrocytes and their potential significance. Interactions with neurons, microglia, and endothelial cells are also considered. This article highlights the critical role of astrocytes in the CNS response to ischemic injury. ยฉ 2005 Wileyโ€Liss, Inc.

๐Ÿ“œ SIMILAR VOLUMES

Neuroprotective role of astrocytes in ce
Neuroprotective role of astrocytes in cerebral ischemia: Focus on ischemic preconditioning
โœ George Trendelenburg; Ulrich Dirnagl ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 215 KB

## Abstract Following focal cerebral ischemia (โ€œstrokeโ€) a complex and dynamic interaction of vascular cells, glial cells, and neurons determines the extent of the ensuing lesion. Traditionally, the focus has been on mechanisms of __damage__, while recently it has become clear that __endogenous mec

Failure and function of intracellular pH
Failure and function of intracellular pH regulation in acute hypoxic-ischemic injury of astrocytes
โœ Mitchell Chesler ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 204 KB

## Abstract Astrocytes can die rapidly following ischemic and traumatic injury to the CNS. Brain acidโ€“base status has featured prominently in theories of acute astrocyte injury. Failure of astrocyte pH regulation can lead to cell loss under conditions of severe acidosis. By contrast, the function o

Astrocytic swelling in cerebral ischemia
Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy
โœ Harold K. Kimelberg ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 221 KB ๐Ÿ‘ 1 views

## Abstract In this viewpoint article, I summarize data showing that the astrocytic swelling that occurs early after the acute CNS pathologies ischemia and traumatic brain injury is damaging. We have proposed that one reason may be the release of excitatory amino acids (EAA) via volumeโ€activated an