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Astatine-211: Its possible applications in cancer therapy

✍ Scribed by I. Brown

Publisher
Elsevier Science
Year
1986
Weight
741 KB
Volume
37
Category
Article
ISSN
0883-2889

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✦ Synopsis

The cyclotron-produced radiohalogen, 211At, is eminently suitable as a possible therapeutic radionuclide. It decays by the emission of 6.8 MeV mean energy alpha-particles, which from a radiobiological viewpoint are of near optimal therapeutic LET. This paper reviews developments in the possible application of [211At]astato-labelled molecules as potential anti-tumour agents. Additionally, radio-dosimetric evidence is presented, and its implications for human cancer therapy are discussed.

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