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Associations between DNA double strand breaks and N7-methyldeoxyguanosine in human sperm and fertility outcomes

✍ Scribed by Altakroni, Bashar; Stocks, Jill; Brison, Daniel; Povey, Andrew

Book ID
127291378
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
80 KB
Volume
229
Category
Article
ISSN
0378-4274

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## Abstract Wortmannin (WM) is a potent inhibitor of the catalytic sub‐unit of DNA‐PK, which is involved in one pathway of DNA double‐strand break (DSB) rejoining, and of ATM, which functions upstream in the p53 signaling pathway. WM is known to be an efficient radiosensitizer in a variety of mamma