## Abstract A number of molecular genetic studies have investigated if serotonin (5βHT) receptor subtypes are involved in the pathogenesis of depression, suicidal behavior, aggression, and impulsive behavior. Existence of many receptor subtypes for a single transmitter permits a great diversity of
Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts
β Scribed by Concepcion Vaquero-Lorenzo; Enrique Baca-Garcia; Montserrat Diaz-Hernandez; M. Mercedes Perez-Rodriguez; Pablo Fernandez-Navarro; Lucas Giner; Juan J. Carballo; Jeronimo Saiz-Ruiz; Jose Fernandez-Piqueras; Enrique Baca Baldomero; Jose de Leon; Maria A. Oquendo
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 66 KB
- Volume
- 147B
- Category
- Article
- ISSN
- 1552-4841
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
There is evidence indicating that density of 5-HT2A receptors is altered in brain regions of depressed suicide victims and in platelets of suicidal subjects with major depression or schizophrenia. Recent studies have also shown an association between the allele C of 102T/C polymorphism in the 5-HT2A
Possible involvement of receptors in the pathogenesis of schizophrenia has been suggested. In this study we searched systematically for polymorphisms in the 5-franking region of the 1 receptor. Genetic variation in this region could reduce the expression of the gene, and this suggestion is compatibl