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Association study of MDR1 and 5-HT2C genetic polymorphisms and antipsychotic-induced metabolic disturbances in female patients with schizophrenia

✍ Scribed by Kuzman, M R; Medved, V; Bozina, N; Grubišin, J; Jovanovic, N; Sertic, J

Book ID
110075536
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
473 KB
Volume
11
Category
Article
ISSN
1470-269X

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✍ Arun K. Tiwari; Clement C. Zai; Herbert Y. Meltzer; Jeffrey A. Lieberman; Daniel 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 111 KB

## Abstract ## Objective Atypical antipsychotic drugs, in particular clozapine and olanzapine, influence cellular lipogenesis and are associated with metabolic side effects including weight gain. Insulin induced gene 2 (INSIG2) mediates feedback control of lipid synthesis and polymorphisms in the