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Association of two functional polymorphisms in the CCR5 gene with juvenile rheumatoid arthritis

✍ Scribed by Prahalad, S; Bohnsack, J F; Jorde, L B; Whiting, A; Clifford, B; Dunn, D; Weiss, R; Moroldo, M; Thompson, S D; Glass, D N

Book ID
110037823
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
152 KB
Volume
7
Category
Article
ISSN
1466-4879

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## Abstract ## Objective Recent findings suggest that interferon regulatory factor 5 (IRF‐5) may play a crucial role in several cellular processes, including the transcription of genes for inflammatory cytokines. Two genetic variants of the __IRF5__ gene (rs2004640 in exon 1 and rs2280714 in the 3