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Association of TNF-alpha gene promoter polymorphism with narcolepsy-cataplexy in Koreans

✍ Scribed by M.H. Park; E.Y. Roh; H. Park; S.J. Kim; D.U. Jeong

Book ID
116530612
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
21 KB
Volume
65
Category
Article
ISSN
0198-8859

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The striking evidence of almost 100% association of narcolepsy with human leukocyte antigens (HLA) DR2(DR15) antigen is an important clue to elucidate the molecular basis of this sleep disorder. The gene for tumor necrosis factor ␣ (TNF ␣) is located in the HLA class II gene cluster. Recent studies