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Association of the κ-opioid system with alcohol dependence

✍ Scribed by Xuei, X; Dick, D; Flury-Wetherill, L; Tian, H-J; Agrawal, A; Bierut, L; Goate, A; Bucholz, K; Schuckit, M; Nurnberger, J

Book ID
110060160
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
248 KB
Volume
11
Category
Article
ISSN
1359-4184

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Genetic association studies have implicated the TaqI A1 allele of the human dopamine D2 receptor gene (DRD2) as a riskdetermining factor for alcohol dependency. However, as alcoholism is a disease of polygenic inheritance, the percentage of overall disease variance explained by the TaqI A1 allele is