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Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case-control study and meta-analysis

✍ Scribed by Crispim, D.; Maia, A. L.; Dora, J. M.; Machado, W. E.; Rheinheimer, J.


Book ID
115450384
Publisher
Bioscientifica
Year
2010
Tongue
English
Weight
177 KB
Volume
163
Category
Article
ISSN
0804-4643

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The type 2 deiodinase Thr92Ala polymorph
✍ Karen A Heemstra; Hendrieke Hoftijzer; Wendy M van der Deure; Robin P Peeters; N πŸ“‚ Article πŸ“… 2010 πŸ› American Society for Bone and Mineral Research 🌐 English βš– 124 KB

## Abstract The role of type 2 deiodinase (D2) in the human skeleton remains unclear. The D2 polymorphism Thr92Ala has been associated with lower enzymatic activity, which could result in lower local triiodothyronine (T~3~) availability in bone. We therefore hypothesized that the D2 Thr92Ala polymo