The type 2 deiodinase Thr92Ala polymorph
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Karen A Heemstra; Hendrieke Hoftijzer; Wendy M van der Deure; Robin P Peeters; N
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Article
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2010
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American Society for Bone and Mineral Research
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English
β 124 KB
## Abstract The role of type 2 deiodinase (D2) in the human skeleton remains unclear. The D2 polymorphism Thr92Ala has been associated with lower enzymatic activity, which could result in lower local triiodothyronine (T~3~) availability in bone. We therefore hypothesized that the D2 Thr92Ala polymo