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Association of the MAPT locus with Parkinson’s disease

✍ Scribed by C. Wider; C. Vilariño-Güell; B. Jasinska-Myga; M. G. Heckman; A. I. Soto-Ortolaza; S. A. Cobb; J. O. Aasly; J. M. Gibson; T. Lynch; R. J. Uitti; Z. K. Wszolek; M. J. Farrer; O. A. Ross

Book ID
111066175
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
95 KB
Volume
17
Category
Article
ISSN
1351-5101

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## Abstract The __MAPT__ gene that encodes Tau is located on chromosome 17q21, in a region, which has evolved to form two major haplotypes, H1 and H2. There is strong evidence that the H1 haplotype, and a sub‐haplotype (H1C), are overrepresented and associated with increased risk for the sporadic t