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Association of the –2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis

✍ Scribed by L. R. Lard; F. A. van Gaalen; J. J. M. Schonkeren; E. J. Pieterman; G. Stoeken; K. Vos; R. G. H. H. Nelissen; R. G. J. Westendorp; R. C. Hoeben; F. C. Breedveld; R. E. M. Toes; T. W. J. Huizinga


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
131 KB
Volume
48
Category
Article
ISSN
0004-3591

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## Objective Recent evidence has highlighted a major genetic contribution to radiographic damage in rheumatoid arthritis (RA). The objective of this study was to determine whether genetic variants in the loci for interleukin-1 (IL-1), IL-6, IL-10, protein tyrosine phosphatase N22 (PTPN22), and sele