Association of SNPs in genes involved in folate metabolism with the risk of congenital heart disease
β Scribed by Wang, Benjing; Liu, Minjuan; Yan, Wenhua; Mao, Jun; Jiang, Dong; Li, Hong; Chen, Ying
- Book ID
- 125450972
- Publisher
- Informa plc
- Year
- 2013
- Tongue
- English
- Weight
- 665 KB
- Volume
- 26
- Category
- Article
- ISSN
- 1476-7058
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## Abstract Cardiac abnormalities are one of the most common congenital defects observed in individuals with Down syndrome. Considerable research has implicated both folate deficiency and genetic variation in folate pathway genes with birth defects, including both congenital heart defects (CHD) and
BACKGROUND: Genetic variation in the folate metabolic pathway may influence the risk of congenital heart defects. This study was undertaken to assess the associations between the inherited and maternal genotypes for variants in folate-related genes and the risk of a composite heart phenotype that in