Association of skin malignancies with various and multiple carcinogenic and noncarcinogenic human papillomaviruses in renal transplant recipients
✍ Scribed by Sylvie Euvrard; Yvette Chardonnet; Claire Pouteil-Noble; Jean Kanitakis; Marie Christine Chignol; Jean Thivolet; Jean Louis Touraine
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 895 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
Background. Organ transplant recipients receiving immunosuppressive treatment are prone to skin carcinomas on sun-exposed areas, and the frequency of such carcinomas in the long term reaches 40%. These carcinomas primarily are squamous cell carcinomas (SCC), which often are preceded by viral warts and premalignant keratoses. Human papillomaviruses (HPV) with other cocarcinogenic factors have been reported to play a role in the development of carcinomas in these patients.
Methods. Five hundred renal-graft recipients referred to our department were examined for the presence of warts, precancerous keratoses, Bowen disease, keratoacanthomas, and basal and squamous cell carcinomas. Adequate material for histologic and virologic examination was obtained from 24 patients. An in situ molecular hybridization technique was performed using biotinylated DNA probes for HPV types l a , 2a, 5, 16, and 18 under stringent conditions.
Results. HPV DNA was detected in 44 of 86 specimens, including 14 of 17 warts, 4 of 17 premalignant keratoses, 1 of 4 Bowen disease lesions, 8 of 12 keratoacanthomas, 3 of 4 tumors in which distinction between kera-