Association of Serum Selenium with Selected Cardiovascular Risk Factors

✍ Scribed by A. Menditto; F. Chiodo; S. Giampaoli; A. Menotti; G. Ricci; G.C. Urbinati; F. Angelico; M. Arca; A. Bucci; A.M. Buongiorno; D. Consalvi; R. Conti; G. Dangelo; A. Defilippis; M. Delben; E. Delmonaco; S. Fazio; A. Montali; F. Pannozzo; A. Pontecorvi; P. Ricci; L. Sibilia; G.L. Sotis; C. Stefanutti; R. Volpe; S. Barzotti; M. Capelli; R. Capocaccia; G. Dicarlo; F. Dima; C. Lonoce; P. Lombari; M. Pasquali; A. Santaquilani; A. Verdecchia; G. Morisi

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 490 KB
• Volume: 51
• Category: Article
• ISSN: 0026-265X
• DOI: 10.1006/mchj.1995.1022

✦ Synopsis

The association of serum selenium ( (\mathrm{S}-\mathrm{Se}) ) with selected cardiovascular risk factors has been studied in 3404 ( 1520 men, 1884 women) of 4699 subjects aged (20-73) years, who underwent a comprehensive examination between April 1986 and December 1987 within the framework of the Di.S.Co. Research Project of the National Research Council. Mean S-Se concentrations were 1.163 (SD 0.170() \mu \mathrm{mol} / /) iter, (1.156(0.163) \mu \mathrm{mol} /) liter, and (1.171(0.179)) (\mu \mathrm{mol} /) iter in the total group, and female and male subjects, respectively. The difference by sex was statistically significant ( (F=6.97, P=0.0083) ). In male subjects (S)-Se levels were inversely associated to age (simple correlation coefficient, (r=-0.2135, P<0.001) ), alcohol consumption (Alcohol, (r=-0.0688, P<0.01) ), smoking habit (Smoke, (r=-0.0663, P<) 0.01 ), body mass index (BMI, (r=-0.0596, P<0.02) ), and lognormal transformation of triglycerides (Ln-Trig, (r=-0.0767, P<0.005) ). In multiple regression analysis Age, Smoke, Ln-Trig, and Alcohol remained significantly and inversely related to S-Se; a significant direct association of S-Se to high-density lipoprotein cholesterol (HDL) and nonHDL cholesterol (non-HDL) was also pointed out. In female subjects, S-Se was directly related to HDL ( (r=0.1436, P<0.001) ) and non-HDL ((r=0.0967, P<0.001)). In multiple regression analysis (\mathrm{S})-Se was directly related to both HDL and non-HDL and an inverse significant association of S-Se to Age and Alcohol was evidenced. In multivariate regression models analyzing systolic (SBP), diastolic (DBP), and mean blood pressure (MBP) as dependent variables, S-Se was a weak significant positive predictor in male but not in female subjects. 1995 Academic Press. Inc