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Association of prenatal vascular disruptions with decreased maternal age

✍ Scribed by Lubinsky, Mark S.

Book ID
101215993
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
59 KB
Volume
69
Category
Article
ISSN
0148-7299

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✦ Synopsis

Disruptions of fetal structures can create a variety of congenital anomalies. Some apparent prenatal vascular disruptions associate strongly with decreased maternal age, and are rare with older mothers. This is well-documented for gastroschisis, but similar findings with hydranencephaly suggest a general phenomenon that may also involve porencephaly, septo-optic dysplasia, early body stalk disruptions, certain hemifacial anomalies, and other findings. Prenatal vascular disruption may be a common cause of congenital anomalies, but its nature is unknown, and obvious environmental confounders associated with decreased maternal age may have only relatively small contributions. A protective effect for pregnancies of older mothers also remains a possibility. Am.

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