Association of polycystic kidney disease and an HLA haplotype within a family clan

✍ Scribed by Xu, L. X.

• Book ID: 104709930
• Publisher: Springer
• Year: 1990
• Tongue: English
• Weight: 132 KB
• Volume: 18
• Category: Article
• ISSN: 0300-5623
• DOI: 10.1007/bf00295857

✦ Synopsis

Nine members of a Chinese family underwent for HLA-A, -B. and -DR typing using microlymphocytotoxicity technique. The results of genotyping of the family showed that all four individuals who suffered from polycystic kidney disease shared the HLA-A9(Aw24), -Bw22, and -DR5 haplotype. It indicated that polycystic kidney disease was associated with an HLA haplotype in the family. We suggested that the HLA-A9(Aw24), -Bw22, -DR5 chromosome might carry the susceptibility gene of polycystic kidney disease in this family.