Association of peroxisome proliferator-activated receptor gamma polymorphisms with inflammatory bowel disease in a Hungarian cohort

✍ Scribed by Szilard Poliska; Andras Penyige; Peter Laszlo Lakatos;; the Hungarian IBD Study Group; Maria Papp; Karoly Palatka; Laszlo Lakatos; Tamas Molnar; Laszlo Nagy

• Publisher: John Wiley and Sons
• Year: 2012
• Tongue: English
• Weight: 853 KB
• Volume: 18
• Category: Article
• ISSN: 1078-0998
• DOI: 10.1002/ibd.21798

✦ Synopsis

Background: Inflammatory bowel disease (IBD) shows increasing incidence in the last few years in Eastern Europe, including Hungary. Since genetic susceptibility of patients plays an important role in the development and pathogenesis of IBD, it is important to identify new susceptibility genes. Peroxisome proliferator-activated receptor gamma (PPARc) is expressed in the colon and has protective effects against inflammatory processes. Our aim was to examine the association of four polymorphisms of PPARc in a well-characterized Hungarian IBD cohort.

Methods: In all, 575 Crohn's disease (CD), 103 ulcerative colitis (UC) patients, and 486 sex-and age-matched controls were examined. Four polymorphisms of PPARc (rs10865710 [C-681G], rs2067819, rs3892175, and rs1801282 [Pro12Ala]) were genotyped by TaqMan genotyping assays.

Results: The Pro12Ala polymorphism showed significant association with CD when the frequencies of the homozygous variants (Pro/Pro vs. Ala/Ala) were compared. The minor Ala/Ala genotype was significantly less frequent in CD patients compared to the controls (odds ratio [OR] ¼ 0.33; 95% confidence interval [CI] ¼ 012-0.94; P ¼ 0.03), suggesting a potential protective effect of the Ala allele. The GAGG haplotype of PPARc confers a protective effect in CD; however, it is not significant, but in UC it has a protective effect with a significant level (OR ¼ 0.14; 95% CI: 0.05-0.42; P ¼ 3.78 Â 10 À5 ), while GAGC increases the risk of UC (OR ¼ 6.70; 95% CI: 3.41-13.17; P ¼ 3.85 Â 10 À10 ).

Conclusions:

In the present study we demonstrated a significant association between PPARc polymorphisms and the development of CD and UC at single loci level and also in haplotype combinations.