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Association of p53 Arg72Pro Polymorphism with Esophageal Cancer: A Meta-Analysis Based on 14 Case-Control Studies

✍ Scribed by Zhao, Lanjun; Zhao, Xilong; Wu, Xiaoming; Tang, Wenru


Book ID
120544459
Publisher
Mary Ann Liebert
Year
2013
Tongue
English
Weight
260 KB
Volume
17
Category
Article
ISSN
1945-0265

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## Abstract Arg72Pro is a common polymorphism in __TP53,__ showing differences in its biological functions. Case‐control studies have been performed to elucidate the role of Arg72Pro in cancer, although the results are conflicting and heterogeneous. Here, we analyzed pooled data from case‐control s

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## Background Emerging evidence has shown that __p53__gene participates in human carcinogenesis as tumor suppressors. Polymorphism of __p53__ gene codon 72 Arg/Pro (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis. It has been suggested that __p5