Association of p53 Arg72Pro Polymorphism with Esophageal Cancer: A Meta-Analysis Based on 14 Case-Control Studies
β Scribed by Zhao, Lanjun; Zhao, Xilong; Wu, Xiaoming; Tang, Wenru
- Book ID
- 120544459
- Publisher
- Mary Ann Liebert
- Year
- 2013
- Tongue
- English
- Weight
- 260 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1945-0265
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## Abstract Arg72Pro is a common polymorphism in __TP53,__ showing differences in its biological functions. Caseβcontrol studies have been performed to elucidate the role of Arg72Pro in cancer, although the results are conflicting and heterogeneous. Here, we analyzed pooled data from caseβcontrol s
## Background Emerging evidence has shown that __p53__gene participates in human carcinogenesis as tumor suppressors. Polymorphism of __p53__ gene codon 72 Arg/Pro (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis. It has been suggested that __p5