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Association of p53 and BCL-2 expression with Epstein-Barr virus infection in the cancers of head and neck

✍ Scribed by Hui Jun Yang; Young Jun Cho; Hee Sung Kim; Mee Soo Chang; Myung-Whun Sung; Woo Ho Kim

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
608 KB
Volume
23
Category
Article
ISSN
1043-3074

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✦ Synopsis

Background:

Reports that have both evaluated the site-specific epstein-barr virus (ebv) infection and compared it with the expression of the ebv-related proto-oncogenes and tumor suppressor genes in the various cancers of head and neck are scarce.

Methods:

Thirty-eight nasopharyngeal carcinoma (npc) cases, 32 oropharyngeal or hypopharyngeal carcinoma (opc/hpc) cases, and 93 laryngeal carcinoma (lc) cases were evaluated with in situ hybridization on ebv-encoded small rna (eber) and immunohistochemical assessments of the p53, bcl-2, and epidermal growth factor receptor (egfr) by use of formalin-fixed paraffin-embedded tissue array slides.

Results:

The expression of viral ebers was observed in more than two thirds (71.1%) of the npc cases. in contrast, only 1 case of opc and none of the hpc or lc cases exhibited ebv positivity. in the nonkeratinizing npc, the ebv positivity was significantly associated with both frequent p53 overexpression (p =.033) and bcl-2 expression (p =.001). in the ebv-positive nonkeratinizing npc, a correlation between p53 overexpression and the tumor infiltration lymphocyte (til) density was noted (p =.012).

Conclusions:

A site-specific expression of viral eber was demonstrated in the head and neck cancers, which suggests an important role for both p53 and bcl-2 in the carcinogenesis of an ebv-infected npc. the correlation between p53 overexpression and the til density in the ebv-infected npc suggests that the product of a lymphoepithelial interaction, such as a20, can induce a dysfunctional p53 protein.

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