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Association of monoamine oxidase (MAO) activity with alcoholism and alcoholic subtypes

โœ Scribed by Devor, Eric J. ;Cloninger, C. Robert ;Hoffman, Paula L. ;Tabakoff, Boris

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
576 KB
Volume
48
Category
Article
ISSN
0148-7299

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โœฆ Synopsis

A familial/genetic study of platelet monoamine oxidase (MAO) activity in alcoholics was carried out. M A 0 activities were determined using phenylethylamine (PEA) as substrate at K, concentration (1.2 pM) and at saturating concentration (12.0 pM). Complex segregation analysis of familial data indicated a single major gene mode of transmission of activity at both substrate concentrations. In addition, the present sample size (13 families, 108 members) proved sufficient to allow correlation analysis of enzyme activity with affection status and clinical subtypes of affecteds. M A 0 activity was significantly correlated with alcoholism at both K, and saturating substrate concentrations and a significant correlation between low M A 0 activity and Cloninger Type I1 alcoholism was seen at K, substrate concentration. These results confirm a hierarchical cosegregation of platelet M A 0 activity and alcoholism suggesting that MA0 activity warrants continued status as a marker in alcoholism.

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