Association of mannose-binding lectin gene (MBL2) polymorphisms with rheumatoid arthritis in an Indian cohort of case-control samples

Haplotype analysis in simplex families a

Haplotype analysis in simplex families and novel analytic approaches in a case–control cohort reveal no evidence of association of the CTLA-4 gene with rheumatoid arthritis

✍ Anne Barton; Francine Jury; Stephen Eyre; John Bowes; Anne Hinks; Daniel Ward; J 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 63 KB 👁 3 views

## Abstract ## Objective Cytotoxic T lymphocyte–associated antigen 4 (CTLA‐4) is a negative regulator of T cells and is, therefore, a strong candidate susceptibility gene for T cell–mediated autoimmune diseases. The association of CTLA‐4 single‐nucleotide polymorphisms (SNPs) with rheumatoid arthr