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Association of mammalian cell death with a specific endonucleolytic degradation of DNA

✍ Scribed by WILLIAMS, JERRY R.; LITTLE, JOHN B.; SHIPLEY, WILLIAM U.

Book ID
109693875
Publisher
Nature Publishing Group
Year
1974
Tongue
English
Weight
196 KB
Volume
252
Category
Article
ISSN
0028-0836

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So far nine human aspartate-specific cysteine proteases (ASCPs) have been identified and cloned in our lab and others. Their sequence and structural homology to the nematode Ced-3 implicated them in the cell death pathway of mammalian cells. Recent evidence suggests that ASCPs initiate apoptosis by