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Association of JAG1 with Bone Mineral Density and Osteoporotic Fractures: A Genome-wide Association Study and Follow-up Replication Studies

✍ Scribed by Annie W.C. Kung; Su-Mei Xiao; Stacey Cherny; Gloria H.Y. Li; Yi Gao; Gloria Tso; Kam S. Lau; Keith D.K. Luk; Jian-min Liu; Bin Cui; Min-Jia Zhang; Zhen-lin Zhang; Jin-wei He; Hua Yue; Wia-bo Xia; Lian-mei Luo; Shu-li He; Douglas P. Kiel; David Karasik; Yi-Hsiang Hsu; L. Adrienne Cupples; Serkalem Demissie; Unnur Styrkarsdottir; Bjarni V. Halldorsson; Gunnar Sigurdsson; Unnur Thorsteinsdottir; Kari Stefansson; J. Brent Richards; Guangju Zhai; Nicole Soranzo; Ana Valdes; Tim D. Spector; Pak C. Sham


Book ID
113422757
Publisher
American Society of Human Genetics
Year
2010
Tongue
English
Weight
490 KB
Volume
86
Category
Article
ISSN
0002-9297

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Bone mineral density (BMD) achieved during young adulthood (peak BMD) is one of the major determinants of osteoporotic fracture in later life. Genetic variants associated with BMD have been identified by three recent genome-wide association studies. The most significant single-nucleotide polymorphis