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Association of interleukin-18 gene polymorphism with asthma in Chinese patients

✍ Scribed by Cheng-Chun Lee; Wei-Yong Lin; Lei Wan; Yuhsin Tsai; Chang-Hai Tsai; Chung-Ming Huang; Chih-Ping Chen; Fuu-Jen Tsai

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
135 KB
Volume
22
Category
Article
ISSN
0887-8013

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✦ Synopsis

Abstract

Like other allergic diseases, asthma results from multiple conditions. Asthmatic beginning and severity are mediated by both environmental and genetic factors. In asthma studies, important work is realization of the genetic background and identification of genetic factors resulting in asthma development and phenomena. Here, we investigated whether interleukin (IL)‐18 single nucleotide polymorphisms (SNPs) are involved in Chinese asthma patients. IL‐18 (IL‐18) SNP was detected by polymerase chain reaction (PCR)‐based restriction analysis in 201 patients with asthma and 60 normal controls. Significant differences were found in the genotype distribution of IL‐18 SNP between asthma patients and controls (P=0.000003). Allelic frequency of the IL‐18 gene distinguished asthma patients from controls (P=0.000066). The results revealed a significant difference between asthma patients and normal controls in IL‐18 SNP and a statistical correlation between IL‐18 polymorphisms (105A/C) and asthma formation. We concluded that Chinese who carry the C/C homozygote of the IL‐18‐105A/C gene polymorphism in coding regions may have a higher risk of developing asthma. J. Clin. Lab. Anal. 22:39–44, 2008. Β© 2008 Wiley‐Liss, Inc.

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