𝔖 Bobbio Scriptorium
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Association of hepatitis C virus carrier state with the occurrence of hepatitis C virus core antibodies

✍ Scribed by Hendrik Claeys; André Volckaerts; Hans D. Beenhouwer; Carl Vermylen

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
707 KB
Volume
36
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

An enzyme immunoassay (EIA) was developed for the determination of antibodies against the “putative” core protein of hepatitis C virus (HCV). Antigens used were recombinant fragments (amino acids 6‐77 or 6‐143) of the HCV core protein, produced in Escherichia coli with truncated hepatitis B core (HBc) as fusion protein.

Evaluation of 385 sera positive for HCV antibodies by first generation EIA, revealed 98 (25.4%) with HCV core antibodies. HCV‐RNA, determined by the polymerase chain reaction (PCR), was exclusively found in the sera positive for HCV core antibodies (89 PCR positives). In random screening of 3,708 sera, 3 sera with HCV core antibodies were found PCR positive. Only 2 of these sera were positive in the first generation EIA

It is concluded that HCV core antibody determination is a reliable test for identifying HCV carriers among blood donors.

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