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Association of glucose transporter 1 polymorphisms with type 2 diabetes in the Tunisian population

✍ Scribed by K. Makni; F. Mnif; M. Boudawara; N. Hamza; N. Rekik; M. Abid; A. Rebaï; F. Jarraya; C. Granier; H. Ayadi

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
97 KB
Volume
24
Category
Article
ISSN
1520-7552

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✦ Synopsis

Abstract

Background

T2DM is a complex metabolic disease. Genetic studies on T2DM have been of little help so far because several genetic association studies have shown conflicting results. In this study, we report the findings of a case‐control study on three SNPs in the GLUT1 gene. For this, we investigated the association of GLUT1 genotypes and haplotypes with T2DM.

Research Design and Methods

All 273 T2DM subjects (cases) and 343 healthy subjects (controls) were genotyped using the polymerase chain reaction restriction fragment length polymorphism.

Results

Results showed that the GT genotype of XbaI SNP could increase the risk of susceptibility to T2DM to 2.4 and that TAT is a ‘risk haplotype’ conferring a risk of 3.4 to T2DM.

Conclusion

The TAT haplotype of the GLUT1 gene confers susceptibility to T2DM in the Tunisian population. Copyright © 2008 John Wiley & Sons, Ltd.

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