Association of E-cadherin, matrix metalloproteinases, and tissue inhibitors of metalloproteinases with the progression and metastasis of hepatocellular carcinoma
โ Scribed by Gao, Zu-hua; Tretiakova, Maria S; Liu, Wen-hua; Gong, Can; Farris, Peter D; Hart, John
- Book ID
- 109888378
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 255 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0893-3952
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Degradation of the extracellular matrix (ECM) is an essential step in tumour invasion and metastasis. The matrix metalloproteinases (MMPs) each have different substrate specificities within the ECM and are important in its degradation. MMP activity is dependent on the levels of activated MMP and tis
## Background and Objectives: The objective was to evaluate the potent role of matrix metalloproteinases(MMPs) and the tissue inhibitors of metalloproteinases(TIMPs) in processes leading to metastasis and local invasiveness of Chinese human ductal adenocarcinomas of the pancreas. We also evaluated